Have you ever found yourself in a pinch, craving something warm, cheesy, and utterly satisfying but without the time for a lengthy meal prep? Enter the High-Protein Keto Calzone, a delightful dish that transforms your weeknight dinners into a breeze of flavor and satisfaction. Packed with seasoned ground chicken and zesty pepperoni, this calzone is not only a low-carb powerhouse but also quick to whip up, taking just 20 minutes from start to finish. Whether you’re fuelled by a keto diet or simply looking for a healthy alternative to conventional takeout, this recipe checks all the boxes. Plus, it’s versatile enough to accommodate various fillings, from vibrant spinach to savory mushrooms. What will you add to yours?

Why This Calzone Will Become Your Favorite?
Quick and Easy: This High-Protein Keto Calzone is a lifesaver for busy weeknights, taking only 20 minutes from prep to plate, allowing you to enjoy a delicious meal in no time.
Flavor Explosion: Bursting with flavors of seasoned ground chicken and pepperoni, each bite is a savory delight that’s bound to impress every palate.
Versatility at Its Finest: Customize with mushrooms or spinach as you please, tailoring this calzone to your taste and dietary needs. Add unique twists with different cheeses or veggies, making it your own!
Crowd-Pleasing Comfort: Perfect for family dinners or friendly gatherings, this dish offers a guilt-free indulgence the whole crew will adore. Pair it with a refreshing side salad or Keto Garlic Mushroom for a complete meal!
Nutritional Powerhouse: Not only is it low-carb, but it’s high in protein, making it a great option for those pursuing a healthier lifestyle without sacrificing flavor.
High-Protein Keto Calzone Ingredients
For the Calzone
• Ground Chicken – This is the primary protein source, and you can easily substitute it with ground turkey or beef for varied flavors.
• Mozzarella Cheese – Offers a gooey and satisfying texture; opt for low-fat mozzarella or vegan cheese for a lighter or dairy-free version.
• Pepperoni – Adds a savory zing; swap it for turkey pepperoni or omit it entirely for a vegetarian delight.
• Italian Seasonings – Enhances the overall flavor; feel free to tweak the mix based on your personal tastes or substitute with fresh herbs for freshness.
Optional Add-Ins
• Mushrooms – Adds delightful texture and nutrients; swap for bell peppers or spinach if you prefer a different taste profile.
For Baking
• Parchment Paper – Essential for baking without sticking; a silicone baking mat is a great alternative if you have one handy.
• Beaten Egg – Gives a beautifully golden crust; use milk or a dairy-free option as an egg wash alternative for a vegan calzone.
With these ingredients ready to go, you’re just a few steps away from creating a scrumptious High-Protein Keto Calzone that’s sure to become a weeknight favorite!
Step‑by‑Step Instructions for High-Protein Keto Calzone
Step 1: Gather Your Ingredients
Start by collecting all the necessary ingredients for the High-Protein Keto Calzone. Having everything at hand will streamline your cooking process. Make sure to prepare ground chicken, mozzarella cheese, pepperoni, Italian seasonings, and any optional add-ins like mushrooms or spinach. Preheat your air fryer to 350°F so it’s ready for cooking once you finish assembling your calzone.
Step 2: Mix the Filling
In a large mixing bowl, combine the ground chicken with Italian seasonings and any optional ingredients you wish to add. Use your hands or a spoon to mix everything together until well combined, ensuring an even distribution of flavors. This step will only take about 2-3 minutes. Once the mixture is ready, you’ll have the tasty filling that makes your High-Protein Keto Calzone truly special.
Step 3: Shape the Calzone
Lay a piece of parchment paper on a clean surface, then take your chicken mixture and shape it into a round circle about half an inch thick. Use your hands to flatten and mold it evenly. The parchment paper will help prevent sticking, making your cooking experience easier. Aim for an even thickness for consistent cooking and a beautifully shaped calzone when it’s done.
Step 4: Add the Filling
Sprinkle a generous layer of mozzarella cheese and pepperoni over one half of the chicken circle you just formed. Be sure to leave some space at the edges to seal your calzone properly. Add any extra ingredients like sautéed mushrooms or spinach if desired, knowing they will enhance the flavor of your High-Protein Keto Calzone. This comforting step is what makes each bite so delicious.
Step 5: Fold and Seal
Carefully fold the other half of the chicken circle over the filling, creating a half-moon shape. Press the edges firmly together to seal in the filling, ensuring it doesn’t ooze out during cooking. For an extra secure seal, you can crimp the edges with a fork. This assembly step might take a minute, but it’s essential for making your calzone look perfect when it’s done.
Step 6: Brush with Egg
Using a pastry brush, gently coat the top of the calzone with a beaten egg. This will create a beautiful golden crust as the calzone bakes, giving it a mouthwatering finish. If you’re looking for an alternative, milk or a dairy-free option will also work. This quick step adds both color and flavor, making your High-Protein Keto Calzone irresistible.
Step 7: Cook in the Air Fryer
Carefully transfer the calzone into the preheated air fryer basket, ensuring it’s centered for even cooking. Set the timer for about 10 minutes at 350°F. Keep an eye on it as it cooks; you’re looking for a crispy, golden exterior that promises a delicious taste. The air fryer will deliver that perfectly crunchy texture while keeping the inside melty.
Step 8: Cool and Serve
Once the cooking time is up, gently remove the calzone from the air fryer and let it cool for a couple of minutes on a cutting board. This brief cooling period allows the cheesy filling to set slightly, making it easier to slice. Cut it into wedges and serve warm, ideally accompanied by a side of keto-friendly marinara for dipping. Enjoy your delightful High-Protein Keto Calzone!

Make Ahead Options
These High-Protein Keto Calzone are a fantastic meal prep solution for busy weeknights! You can prepare the flavor-packed filling of ground chicken, cheese, and seasonings up to 24 hours in advance. Simply combine the ingredients in a bowl, cover, and refrigerate until you’re ready to assemble. To maintain that crispy texture, shape the calzones and brush them with egg just before cooking. You can also freeze uncooked calzones for up to 3 months—just make sure to wrap them tightly in parchment paper and plastic wrap to avoid freezer burn. When ready to enjoy, cook directly from frozen for an additional few minutes in the air fryer. With these make-ahead tips, your High-Protein Keto Calzone will taste just as delicious as if they were freshly made!
What to Serve with High-Protein Keto Calzone
Elevate your meal experience with vibrant sides and refreshing flavors that pair perfectly with this cheesy delight.
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Crispy Side Salad: A fresh mix of greens, cherry tomatoes, and cucumbers tossed in a light vinaigrette provides a crisp, refreshing contrast to the hearty calzone. The crunch will make every bite even more satisfying.
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Steamed Broccoli: This easy-to-make side adds a tender, nutrient-rich element that complements the calzone’s savory filling. Drizzle with lemon juice for a zesty touch!
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Keto Marinara Sauce: A homemade dipping sauce brings an extra layer of flavor, enhancing the delightful cheesy center of the calzone. It’s not just a dip; it’s a flavor explosion!
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Garlic Butter Green Beans: Sautéed in garlic and a hint of butter, these tender green beans create a lovely balance of savory and fresh, making them a crowd-pleasing addition.
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Cauliflower Mash: This creamy, low-carb alternative to mashed potatoes is a rich, comforting side that pairs beautifully with the crispy calzone. You’ll love how well these flavors blend together!
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Zucchini Noodles: Light and refreshing, these noodles can be tossed with olive oil and herbs for a refreshing, low-carb option that keeps the meal light yet fulfilling.
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Sparkling Water with Lemon: A bubbly drink with a hint of citrus keeps the meal refreshing and light. Each sip will cleanse your palate beautifully between bites of the savory calzone.
How to Store and Freeze High-Protein Keto Calzone
Fridge: Keep your High-Protein Keto Calzone wrapped in airtight packaging for up to 2 days; this ensures freshness and maintains the delicious cheesy filling.
Freezer: If you want to store it longer, freeze the calzone for up to 2 months. Wrap it tightly in plastic wrap and aluminum foil to prevent freezer burn.
Reheating: To reheat, simply place the calzone in an air fryer at 350°F for about 5-7 minutes until crispy again, or use an oven at 375°F for 10-15 minutes.
Make-Ahead Tip: You can assemble the calzone ahead of time and store it unbaked in the fridge for up to 24 hours before popping it into the air fryer or oven for a quick dinner.
Expert Tips for High-Protein Keto Calzone
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Even Distribution: Ensure your fillings are evenly distributed to guarantee a balanced flavor profile in each glorious bite of your High-Protein Keto Calzone.
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Avoid Overstuffing: Resist the urge to overstuff your calzone; doing so can cause it to burst during cooking, ruining that perfect golden crust.
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Cooking Alternatives: If you don’t have an air fryer, fear not! Bake your calzone in a conventional oven at 400°F for 15-20 minutes but adjust cooking time as necessary.
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Seal It Well: Press and crimp the edges firmly to prevent any molten cheese from escaping while it cooks, ensuring a delightful filling in every slice.
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Creative Variations: Don’t hesitate to experiment with different fillings or cheeses, turning your High-Protein Keto Calzone into a new favorite every time you make it!
High-Protein Keto Calzone Variations
Feel free to explore these delightful twists to make your High-Protein Keto Calzone even more exciting and personalized!
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Ground Meat Swap: Substitute ground chicken with turkey or beef for varied flavors. Each option will bring a unique taste and texture to your calzone!
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Cheese Variations: Try using provolone or cheddar cheese for a rich and flavorful twist. Mixing cheeses can elevate your dish to a whole new level of gooey goodness.
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Vegetable Boost: Add spinach, bell peppers, or olives for extra nutrients and flavor. These goodies will add vibrant colors and a satisfying crunch that complements the savory fillings beautifully.
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Dairy-Free Option: Swap mozzarella cheese with your favorite vegan cheese for a luscious, dairy-free calzone. This option allows plant-based folks to indulge without missing out on the cheesy goodness!
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Heat It Up: Sprinkle some red pepper flakes or diced jalapeños into your filling for a spicy kick. Just a hint of heat can enhance the flavors and make each bite more adventurous.
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Saucy Surprise: Brush the calzone with a mix of olive oil and garlic before baking for added depth. That garlicky aroma will have everyone salivating before dinner begins!
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Pesto Delight: Spread a thin layer of pesto inside for a burst of herbal flavor. It’s a simple yet effective way to elevate your calzone and give it that Italian touch you’ll adore.
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Keto-Friendly Dipping Sauce: Serve your calzone with a side of keto-friendly marinara for extra flavor, or try a creamy ranch for a fun twist. Dipping adds an interactive element to your dining experience!
With these variations, your High-Protein Keto Calzone can become a new creation every time you make it! Whether you stick to the classic recipe or try something different, your taste buds are in for a treat!

High-Protein Keto Calzone Recipe FAQs
How do I choose ripe ingredients for my High-Protein Keto Calzone?
It’s important to select fresh ingredients for the best flavor. Look for ground chicken that’s vibrant pink and has a fresh smell. Mozzarella should be soft and springy, with no dark spots. If you’re adding vegetables like mushrooms, find ones that are firm to the touch and have a smooth surface, free from dark spots or wrinkles.
How should I store my High-Protein Keto Calzone?
To keep your High-Protein Keto Calzone fresh, wrap it in an airtight container or aluminum foil and store it in the fridge for up to 2 days. This helps preserve the cheesy filling and ensures it remains delicious. If you’re feeling like a meal prep champion, you can also create a few calzones ahead of time for busy nights!
Can I freeze my High-Protein Keto Calzone?
Absolutely! To freeze, wrap the calzone tightly in plastic wrap and then aluminum foil, limiting air exposure to prevent freezer burn. They can be stored for up to 2 months in the freezer. When you’re ready to indulge, simply heat it in the air fryer or oven, as mentioned in the reheating section of the recipe.
What should I do if my calzone bursts while cooking?
If your calzone bursts open, don’t worry too much! It’s likely due to overstuffing or insufficient sealing. Next time, make sure to seal the edges well by pressing firmly and crimping with a fork to avoid leakage. And remember, less is often more when it comes to fillings; try not to overstuff it, so you can achieve that perfect golden crust!
Are there any dietary considerations for pets or allergens I should be aware of?
Always check for allergies when serving homemade food. Some ingredients like pepperoni or cheese may not be suitable for pets, and certain individuals may have sensitivities to dairy. If you have allergies in your household, consider making a vegetarian version of the calzone by omitting animal products and using suitable substitutes like vegan cheese or plant-based meat options.

High-Protein Keto Calzone: Crispy, Cheesy Delight Under 30 Minutes
Ingredients
Equipment
Method
- Gather all the necessary ingredients for the High-Protein Keto Calzone.
- In a large mixing bowl, combine the ground chicken with Italian seasonings and any optional ingredients.
- Lay a piece of parchment paper on a clean surface, then shape the chicken mixture into a circle.
- Sprinkle mozzarella cheese and pepperoni over one half of the chicken circle.
- Fold the other half of the chicken circle over the filling and press the edges to seal.
- Gently coat the top of the calzone with a beaten egg.
- Transfer the calzone into the preheated air fryer and cook for about 10 minutes at 350°F.
- Let the calzone cool for a couple of minutes, then cut into wedges and serve.

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